Jérôme Adda, Christian Decker, Marco Ottaviani, 16 September 2020

There is much riding on the clinical trials currently in search of a COVID-19 vaccine. But for a vaccine to do more good than harm, researchers must remain free from conflicts of interest that could undermine their integrity. This column analyses trial results reported to the ClinicalTrials.gov registry. It finds reassuring evidence for the reliability of ongoing clinical research, but also identifies subtle patterns that regulators should monitor with care, paying particular attention to enforcing the transparency of trials sponsored by smaller companies.

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